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CBD can help ease anxiety symptoms. In fact, according to one study, people with generalized anxiety disorder reported improvements in their symptoms after just 2 months of using CBD oil. CBD helps to reduce the underlying causes of anxiety, rather than simply masking the symptoms. This makes it an excellent natural option for those who want to get back to feeling normal, without the use of pharmaceuticals or harmful side effects.
CBD has been shown to have anxiolytic effects in preclinical animal models of anxiety. For example, CBD reduced the increased anxiety behavior induced by acute restraint stress in rats. It also decreased anticipatory anxiety and skin conductance responses during a single-photon emission computed tomography (SPECT) imaging procedure in healthy humans. Furthermore, systemic CBD reduced anxiety evoked by a public speaking test in people with social anxiety disorder (SAD) and enhanced extinction of fear responses during a contextual fear conditioning experiment in healthy human volunteers.
These anxiolytic effects are mediated by the central nervous system and brain regions involved in modulation of anxiety-like behaviors. CBD has been shown to increase hippocampal AEA production and decrease the activation of tyrosine kinase B receptor (KAR) in the amygdala, which are known to be associated with increased anxiety-related behavior [19]. CBD has also been found to decrease histone H3K9ac in the central amygdala, which is linked to anxiety reactivity and pain [20].
It is important to note that CBD’s anxiolytic effects may differ depending on the context and brain region. For example, in the EPM and VCT anxiety-induced behavior model, CBD’s anxiolytic effects were dependent on 5-HT1AR activation. In contrast, microinjection of CBD into the bed nucleus of the stria terminalis (BNST) and prelimbic cortex of unstressed animals produced anxiogenic-like behavior, but following stress was anxiolytic, partially via GABAA receptor activation.
CBD’s anxiolytic effects are augmented by prior stress exposure and depend on CB1R activation in the prefrontal cortex, hippocampus, and amygdala. CBD has also been found to enhance extinction of learned fear in humans, possibly by modulating hippocampal AEA and suppressing KAR activity.
Anxiety is a common symptom that often co-occurs with sleep disorders. In a small study, CBD reduced anxiety and improved sleep quality in 4 out of 5 participants. In addition, CBD was able to reduce the frequency of nightmares in those with PTSD. These findings indicate that CBD can be used to treat both anxiety and sleep issues in those with PTSD and other mental health conditions. This combination of benefits is particularly promising, since it is known that sleep problems are a significant risk factor for anxiety and depression. This is why cbd for anxiety has become a popular supplement, especially among those suffering from PTSD and other disorders. You can find CBD for anxiety products in tinctures, gummies, and lotions. The best way to take CBD for anxiety is to apply it sublingually, meaning that you place the product beneath your tongue and hold it there for about 30 seconds. This method allows the CBD to be absorbed quickly and begins working to calm you within minutes.
